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O transformations the RMSDD falls to 0.36?and to 0.73 . The translation of the center of mass of 1-126 is 1.3?and rotation around the axis passing through this center is 6?(almost the same as the 5?reported in Ref. (46)). It is clear from Fig. 4c that the white spots in the DDM represent not local distortions but a systematic, albeit not large, difference between the apo- and holo-structures. We
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Ession of MHC class I molecules on uveal melanomas predominantly comprised of spindle cell melanoma cells should be vulnerable to NK cell-mediated surveillance. This would correlate with reduced malignancy that is typically associated with uveal melanomas comprised predominantly of tumor cells with a spindle cell morphology. By contrast, epithelioid uveal melanoma cells, a phenotype that is charac
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It proteasomal cleavage, peptide processing and HLA-binding rules. In recent years, it has become common practice in proteomics research to submit MS/MS data to repositories in order to make them available for further research (30). More recently, this practice is also being followed in the field of immunopeptidomics (17, 28, 31). So far, the large body of publically available MS/ MS data has been
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Ry is MC-dependent at 54 In an initial clinical screen to evaluate whether we could identify an intensity of scald burn injury that required mature cutaneous MCs for development of an ulcer and subsequent remodeling, we compared the injury generated in MC ufficient (WBB6)F1/J mice versus MC-deficient WWv littermates by exposing a 1cm2 area of dorsal epidermis to water heated to 54 , 56 , or 58
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Hypothermia, transarterial or transvenous endovascular cooling, extraluminal vascular cooling, and epidural cerebral cooling [66]. 6.7 Decompressive craniotomy Decompressive craniotomy (DC) is used to treat elevated ICP that is unresponsive to conventional treatment modalities [23]. In addition to infusion of hypertonic solutions, e.g., mannitol, and other medical measures, DC by surgical removal
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Alcium channels and neuron membranes [53]. Animal studies have indicated a beneficial effect of magnesium on outcome such as cognitive function and sensorimotor function after TBI [54?57]. In addition, magnesium sulfate treatment was found to be the most effective choice due to the absence of side effects and comparable efficacy to corticosteroids [58]. But its efficacy in humans is still unknown.
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Script; available in PMC 2010 September 6.Castano et al.PageThe combination therapy produced tumour cures that were not seen with either treatment alone. Furthermore, when mice bearing two tumours had only one treated with the combination of PDT and dendritic cells, the contralateral untreated tumour underwent regression. The presence of tumour-specific lymphocytes was shown by chromium-release CT
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S, as the different chemical forms of each peptide may be separated from each other at the reversed-phase HPLC step. The reagent most frequently used in protein purifications that leads to protein modification is urea (also see APPENDIX 3A). Although urea itself is uncharged and does not directly react with proteins, it decomposes rapidly to form cyanate, which reacts with amino groups.Curr Protoc
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Esentative peptide analysis corresponding to the E1b (BCKDHB) subunit of the BCKDH complex. The peptide LGVSCEVIDLR was detected and quantified in the samples from healthy individuals (chromatogram on the left), but not in the samples from patients (chromatograms on the right). The detection level for the E1b subunit was determined as 19 respect to controls. Therefore, the E1b subunit levels in t
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D: 1249063] Edman P. A method for the determination of the amino acid sequence in peptides. Arch Biochem Biophys. 1949; 22:475?80. Edman P, Begg G. A protein sequenator. Eur J Biochem. 1967; 1:80?1. [PubMed: 6059350] Erdjument-Bromage, H.; Geromanos, S.; Chodera, A.; Tempst, P. Successful peptide sequencing with femtomole level PTH-analysis: A commentary. In: Angelletti, R., editor. Techniques in