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D drastically diminished pulmonary metastatic tumor burden. These data highlight the importance of TXNIP as a potential therapeutic target and prognostic marker in advanced thyroid cancer.HTh74 and C643 cells were obtained from Dr. K. Ain (University of Kentucky, Lexington, KY) with permission from N. E. Heldin (University Hospital, Uppsala, Sweden). TPC1 cells were provided by S. Jhiang (Ohio Sta
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Oscope to enhance visualization. Weekly imaging with IVIS after injection of luciferin was performed to monitor tumor establishment and growth. There were 10?1 mice per group in each experiment, and the experiment was performed two times. (A) Representative images of one mouse per group imaged by IVIS over time are shown. (B) Quantitation of the bioluminescence from one experiment is shown with av
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Oscope to enhance visualization. Weekly imaging with IVIS after injection of luciferin was performed to monitor tumor establishment and growth. There were 10?1 mice per group in each experiment, and the experiment was performed two times. (A) Representative images of one mouse per group imaged by IVIS over time are shown. (B) Quantitation of the bioluminescence from one experiment is shown with av
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Uares () indicate vector control cells, and open diamonds () indicate cells with TXNIP overexpression. In vitro invasion assays were performed on the TXNIP-overexpressing stable HTh74 (C) and T238 (D) cell lines as described in the Methods section. Results from three independent experiments were combined and normalized to the vector control average and graphed with mean plus SEM. *p
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in