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D drastically diminished pulmonary metastatic tumor burden. These data highlight the importance of TXNIP as a potential therapeutic target and prognostic marker in advanced thyroid cancer.HTh74 and C643 cells were obtained from Dr. K. Ain (University of Kentucky, Lexington, KY) with permission from N. E. Heldin (University Hospital, Uppsala, Sweden). TPC1 cells were provided by S. Jhiang (Ohio Sta
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D drastically diminished pulmonary metastatic tumor burden. These data highlight the importance of TXNIP as a potential therapeutic target and prognostic marker in advanced thyroid cancer.HTh74 and C643 cells were obtained from Dr. K. Ain (University of Kentucky, Lexington, KY) with permission from N. E. Heldin (University Hospital, Uppsala, Sweden). TPC1 cells were provided by S. Jhiang (Ohio Sta
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Ed that the degree of glucose uptake was inversely correlated with TXNIP levels in the examined thyroid cancer cell lines. An interesting aspect of thyroid cancer biology relates to its properties on 2-deoxy-2-fluoro-D-glucose positron emission topography computed topography (FDG PET/CT) imaging. FDG PET imaging can be negative in many patients withDTC and distant metastases, and this correlates w
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Ed that the degree of glucose uptake was inversely correlated with TXNIP levels in the examined thyroid cancer cell lines. An interesting aspect of thyroid cancer biology relates to its properties on 2-deoxy-2-fluoro-D-glucose positron emission topography computed topography (FDG PET/CT) imaging. FDG PET imaging can be negative in many patients withDTC and distant metastases, and this correlates w
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Ed that the degree of glucose uptake was inversely correlated with TXNIP levels in the examined thyroid cancer cell lines. An interesting aspect of thyroid cancer biology relates to its properties on 2-deoxy-2-fluoro-D-glucose positron emission topography computed topography (FDG PET/CT) imaging. FDG PET imaging can be negative in many patients withDTC and distant metastases, and this correlates w
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The mechanisms by which TXNIP is expressed and functions in thyroid cancer will improve our understanding of the progression to advanced thyroid cancer and help to develop more effective targeted therapies.MethodsCell lines and maintenanceConclusions In conclusion, we report that TXNIP is a novel tumor suppressor in thyroid cancer. TXNIP is downregulated during the progression from well-differenti
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The mechanisms by which TXNIP is expressed and functions in thyroid cancer will improve our understanding of the progression to advanced thyroid cancer and help to develop more effective targeted therapies.MethodsCell lines and maintenanceConclusions In conclusion, we report that TXNIP is a novel tumor suppressor in thyroid cancer. TXNIP is downregulated during the progression from well-differenti
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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 http://www.molecular-cancer.com/content/13/1/Page 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in
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Ith 10 fetal bovine serum (FBS), non-essential amino acids, 1 mM sodium pyruvate, 1 nM T3, 0.5 g/mL hydrocortisone, 8 ng/mL epidermal growth factor, 25 mM HEPES, and 0.1 mg/mL Primocin. MDA-T41 cells were obtained from G. Clayman (University of Texas MD Anderson Cancer Center, Houston, TX). K1 cells were provided by D. Wynford-Thomas (Cardiff University, Cardiff, UK). T238 were obtained from L. R
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Ith 10 fetal bovine serum (FBS), non-essential amino acids, 1 mM sodium pyruvate, 1 nM T3, 0.5 g/mL hydrocortisone, 8 ng/mL epidermal growth factor, 25 mM HEPES, and 0.1 mg/mL Primocin. MDA-T41 cells were obtained from G. Clayman (University of Texas MD Anderson Cancer Center, Houston, TX). K1 cells were provided by D. Wynford-Thomas (Cardiff University, Cardiff, UK). T238 were obtained from L. R