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Tive comparison, we used the Net Domain Overlap (NDO) score [32] and SCOP or CATH, whichever gave the higher score, as the standard of truth for each query structure. A mathematical description of the NDO scoring scheme is given as a Supplementary Material (NDOscoring.pdf). The estimated standard error of the mean was calculated as s/n where s is the sample standard deviation about the mean and n
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