Dified with Tf or CTB [54]. Furthermore, Pluronic?block copolymers were shown to inhibit caveolae-mediated endocytosis at higher concentrations (0.01 and above) [55]. Even more interestingly they have shown an ability to enhance nuclear import of polyplex-delivered DNA [93]. By interacting with specific membrane microdomains, such as caveolae, polymers and nanomaterials may affect multiple signal
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